The United States will impose new sanctions on Iran in the coming days in the aftermath of its attack on Israel over the weekend with hundreds of drones and missiles, White House national security adviser Jake Sullivan said Tuesday evening.

“Following Iran’s unprecedented air attack against Israel, President Biden is coordinating with allies and partners, including the G7, and with bipartisan leaders in Congress, on a comprehensive response,” Sullivan said in a statement. “In the coming days, the United States will impose new sanctions targeting Iran, including its missile and drone program as well as new sanctions against entities supporting the Islamic Revolutionary Guard Corps (IRGC) and Iran’s Defense Ministry. We anticipate that our allies and partners will soon be following with their own sanctions.”

"These new sanctions and other measures will continue a steady drumbeat of pressure to contain and degrade Iran’s military capacity and effectiveness and confront the full range of its problematic behaviors," Sullivan added, noting that in the last three years, the U.S. has sanctioned 600 individuals and entities linked to terror, terrorism financing and "support for proxy terrorist groups, including Hamas, Hezbollah, the Houthis, and Kataib Hezbollah."

"The pressure will continue," Sullivan pledged. "We will not hesitate to continue to take action, in coordination with allies and partners around the world, and with Congress, to hold the Iranian government accountable for its malicious and destabilizing actions."

After Iran's attack, the U.S. and the United Nations urged de-escalation as leaders in the region called for an end to the war in Gaza and restraint from Israel.

“Ultimately, Israel is going to make its own decisions when it comes to any offensive operation. But our commitment to its self defense is ironclad,” Vedant Patel, a deputy spokesperson for the U.S. State Department told Spectrum News on Tuesday. “However, we're continuing to engage with Israeli officials and regional partners and allies about the need for de-escalation and ensuring that we're not in an all out conflict with Iran.”

“We have been very clear where we are we're not going to be participating in any offensive operation that Israeli partners may undertake,” Patel added.

Israel has said that it plans to retaliate for the attack, which wounded one and damaged an airbase. Iran said they conducted the strike in response to an April 1 airstrike widely blamed on Israel that destroyed what Iran says were consular offices in Syria’s capital Damascus and killed 16 people, including two generals with its paramilitary Revolutionary Guard. Israel, which has repeatedly targeted Iranian officers in Syria and in Lebanon, has not claimed responsibility for the Damascus strike.

Iran has said they have no intention to continue the attacks at this point unless it is attacked in return.

U.N. Secretary-General Antonio Guterres called for “urgent de-escalation” of hostilities in a Monday phone conversation with Iran’s foreign minister. The U.N. chief didn’t speak to any senior Israeli officials, according to a spokesperson. During an emergency Security Council meeting on Sunday, Guterres warned that “the Middle East is on the brink” and it's time to step back.

White House national security spokesperson John Kirby said on Tuesday that President Joe Biden “does not want to see a war with Iran. Don't want to see the conflict widen or deepen.” While Biden spoke with Israeli Prime Minister Benjamin Netanyahu on Saturday night and Patel told Spectrum News on Tuesday that Secretary of State Antony Blinken was engaging with counterparts in Israel, Egypt, Turkey, Saudi Arabia and elsewhere, Kirby said he was unaware of any contact between U.S. officials and Iran.

State Department spokesperson Matthew Miller said there has not been any contact “in the last few days,” but there had been communication in the “past week.”

The majority of Iran’s drones and missiles launched this weekend were shot down by Israel, the U.S. and other allied forces. The sole reported casualty was a wounded girl in southern Israel, and a missile struck an Israeli airbase, causing light damage. Iran stressed that it targeted Israeli facilities involved in the Damascus attack, not civilians or “economic areas.”

Israel and Iran have long been enemies. Israel has been suspected of carrying out assassinations within Iran’s borders and allied groups elsewhere in the region (an Israeli drone strike on a car in southern Lebanon killed a commander with the militant Hezbollah group and wounded two others Tuesday.) Iran has funded Palestinian militant groups for years, including Hamas whose Oct. 7, 2023, attack on southern Israel sparked the war that has killed around 1,500 Israeli citizens and soldiers, and at least 33,843 Palestinians, Gaza’s health ministry said on Tuesday. The ministry does not differentiate between fighters and civilians, but is broadly trusted internationally to provide reliable data and has said that women and children make up most of those killed.

Biden continued to call for a ceasefire in Gaza this week “that will bring [Hamas-held Israeli] hostages home and prevent any conflict from spreading beyond what it already has.” Pakistan and Saudi Arabia on Tuesday called for an immediate cease-fire and uninterrupted delivery of humanitarian aid.

Without directly mentioning an Iranian attack on Israel over the weekend, Saudi Arabia’s Foreign Minister Prince Faisal bin Farhan said during a visit to Pakistan that “we are already in an unstable region, and the humanitarian catastrophe in Gaza is already inflaming the region. We do not need more conflict in our region, we do not need more confrontation in our region, so it is our position that the de-escalation must be everybody’s priority.”

Pakistan’s Foreign Minister Ishaq Dar described the killings in Gaza as “genocide.” Turkey President Recep Tayyip Erdogan accused Western nations of double standards for speaking out against Iran over its weekend attacks on Israel but not condemning Israel for targeting the Iranian consulate in the Syrian capital earlier.

“Israel’s targeting of the Iranian (mission) in Damascus in violation of international laws and the Vienna convention was the last drop," Erdogan said. “Those who remained silent toward Israel’s aggressive attitude immediately raced to condemn Iran’s response.”

The U.S. told Iran they had no involvement in the strike at the time, but blocked a U.N. Security Council resolution condemning it earlier this month.

“We’re continuing to look into it. I don’t have a timetable,” said Miller, the State Department spokesperson, on Tuesday.

And in a call on Tuesday, Italian Defense Minister Guido Crosetto told Israeli Defense Minister Yoav Gallant that “the crossing of a precise red line with the direct attack on Israel, on its territory, is worrying but it is precisely now that we need to be mature and act according to the rules of international law to avoid fuelling the spiral of violence that would see us all defeated,” according to Crosetto’s office. Italy hosts a meeting of G7 foreign ministers beginning on Wednesday, which Blinken still plans on attending through Friday, the State Department confirmed.