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Winfrey's production company says the popular host will make the announcement on her show Friday.

While more details will be made then, the show will fade to black in 2011 after its 25th season on the air.

Fans say they'll be sad to see Oprah go.

"It's kind of devastating, but I understand why. She's been doing this for a long time and if anybody needs a break, it's her," said one Oprah fan.

"I'm really surprised just because right now there aren't that many great daytime TV shows, or nighttime ones. TV now is so much reality shows and Oprah's one of the last few, you know, good talk show hosts out there, I feel like that's non-comedy," said another Oprah fan.

Winfrey started hosting the show in 1984 when it was known as "A.M. Chicago." A year later it was renamed "The Oprah Winfrey Show."

A year after that, it went into syndication and would go on to become one of the most popular and influential TV talk shows of all time.