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Feeling the pressure of that defeat, Clinton's softer side came out in a memorable moment in New Hampshire.

"I just don't want to see us fall backwards, you know? This is very personal for me. It's not just political, it's not just public. I see what's happening and we have to reverse it," said Clinton.

She won the primary the following day.

"Over the last week I listened to you and in the process, I found my own voice," said Clinton.

But over the next two months, Clinton lost 25 primaries and caucuses. She rebounded and won Ohio and Texas, and kept up the momentum to take Pennsylvania. Her late surge wasn't enough.

When the final states went the polls on June 3, Obama secured enough votes to win the Democratic nomination, but Clinton did not concede.

A few days later, she bowed out before thousands of supporters.

"This isn't exactly the party I planned but I sure like the company," said Clinton.

By the end of June, Clinton moved to unify her party.

She and Obama appeared together in Unity, New Hampshire and Clinton enlisted Obama's help to retire millions in campaign debt.

At the party's nomination convention in August, Clinton was celebrated for embracing Obama. She called on the 18 million people who voted for her to back him.

Clinton continued to campaign for her former rival, even though she wasn't picked to be his vice presidential nominee. But Obama came calling with another job offer, Secretary of State.

"If confirmed I will give this assignment, your administration and my country my all," said Clinton.

Clinton is poised to be the nation's top diplomat, leaving her New York Senate seat.

She didn't make history by becoming the first female president, but there's always 2012.